Inovo Pharmaceuticals (NYSE AMEX: INO) said Wednesday that its DNA vaccine has Pennvax-B for prevention of HIV "significant" immune reactions during a clinical study showed the therapy.
The immune system is the body's way of fighting foreign invasion and potentially dangerous cells or antigens. DNA vaccination is a technique to protect the body against disease by injecting DNA genetically modified to produce an immune response. DNA vaccines are so many advantages over conventional vaccines, including the possibility of a wider range of species to induce the immune response.
"They are among the highest immune responses in other tests with the vaccine against HIV DNA vaccines or other platforms, including proteins and viral vectors. However, unlike viral vectors, DNA vaccines do not cause adverse immune reactions in having regard to the carrier, "said President and CEO Dr. Joseph J. Kim
The placebo-controlled study, sponsored by the National Institute of Allergy and Infectious Diseases involved vaccination of 48 healthy volunteers and HIV-negative levels of safety and immune response of the vaccine with the company to assess speech delivered electrical equipment.
The data showed that the response of immune T cells generated by antigen-specific vaccination in most subjects. The CD4 + or CD8 + or T cell responses was observed against at least one vaccine antigen in 61% of those evaluated after two vaccinations.
After three injections, 84% had positive responses assessed for T cells Inovo said cell responses clearly strong antigen-specific CD8 + T also induced by vaccination in 55% of vaccines generated evaluated after three doses.
In addition, samples were tested from eight in the placebo group and were negative for both types of T-cell immune response, which shows that the potential of vaccines to prevent HIV infection.
Inovo previously reported data from a study in animals to the vaccine, it seemed, a 100-fold improvement in the immune response to the supply of electro-speech demonstrated in vivo, compared to injection syringe.
Inovo DNA vaccines have been developed to provide protection against great effort against strains known and emerging pathogens. Clinical programs include HPV / cervical dysphasia and cancer, avian flu and HIV.
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